​The major research interest in Dr. Zhou’s laboratory is related to bile acid- and sphingolipid-mediated signaling in liver diseases, including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic liver disease (ALD), drug-induced liver disease, and cholestatic liver diseases.

 

Bile acids and sphingosine lipids are important signaling molecules and play critical roles in maintaining hepatic and biliary homeostasis. Dysregulation of bile acid or/and sphingosine lipid-mediated signaling pathways is linked to the pathogenesis of various liver diseases.

 

Understanding the roles of bile acids and sphingolipids in regulating hepatic lipid metabolism and biliary function under different pathological conditions will provide a foundation for discovering new diagnostic markers and novel pharmaceutical interventions for the prevention and treatment of different liver diseases.

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Learn more Dr. Zhou Lab Website , Research Gate, Google Scholar